I do it all the time. It's a lot like PFT's point about the way most people experience humor (w/r/t why most people don't care about Carlos Mencia's joke-theft). I'd never use anything from the Best Show or any other comedian in my own work, but I use it in conversation all the time, mostly just to my wife. I've called about three different people soft serve in the past two weeks or so.
I also use Andy Breckmanisms on occasion, but they're a lot harder to pull off, maybe because the radio Andy is more like the real Andy than the radio Tom is like the real Tom. Or maybe Andy's just been at it a lot longer.