I like Depravity's Rainbow. It's got a nice ring to it. I'll run it by Therese.
Others I've been considering:
Spill Your Guts!
Peel Back the Skin!
In addition to the Pynchon backbone,
Depravity's Rainbow suggests that after wading through the sewers, there is color and light. Kind of like that film
The Redemption of Andy Dufresne.
As for your proposed, T.L. Strauss-y titles, I might just go with
Innards Radio.