At the end of the day, it is what it is.
I like these phrases, especially for business conversations, where often you are forced to talk to someone that you have no real desire to talk to but also don't dislike enough to be rude to. These are great things for both of you to be able to say while you think about whatever it is that you would rather think about.
For example:
A: Hey, what do you think about the new tax plan? They're really going to soak us, huh? (thinks about date later that evening).
B: Yeah, man. At the end of the day, it just is what it is (Thinks about basketball game)
A: Yeah, man, exactly.