Response after a brief skimming of this list: I will never watch Titanic, because all the people who told me, "no, seriously, it's really good" were the same people who said that about Forrest fucking Gump, which I watched TWICE just to make sure I wasn't missing anything.
That, and I generally won't see anything on Broadway anymore unless family is in town and they're paying. But to be more specific: Neil LaBute. Don't care! Also, any David Mamet except Glengarry Glen Ross, which I admit is pretty good. And I will never see Stuff Happens in any medium. WHO GIVES A SHIT.
I won't read Chuck Klosterman or Chuck Palaniuk. I know the latter is crap, and the former might be OK, but I'm judging a book by its cover here.
Agreed on Scrubs. I will also never watch House or Boston Legal.
In comics, I avoided Brian Michael Bendis for years, then finally gave in and I'm still ambivalent, leaning towards I-was-right-all-along. Half the time it feels like the guy doesn't understand basic story construction, not to mention that it feels like I'm reading a bowdlerized transcript of the Howard Stern show, but spoken by superheroes. Sometimes it can be pretty good, though.
Now, general thread responses:
I'm just "meh" about a lot of indie rock, including Pavement (I actually like both the Silver Jews and Malkmus' solo stuff better), Neutral Milk Hotel, Animal Collective, Arcade Fire, My Morning Jacket, etc. etc. I don't hate any of it, but I do feel like I'm missing something. Love GBV, though.
I love Lost, Lawrence of Arabia, and The Pogues. I like Rush.
Here is my ultimate sin: I like The Grateful Dead, and not just their studio work.