Doogie Horner, Chip Chantry, Aaron Hertzog and The Feeko Brothers and Secret Pants.
These are all Philly-based comics who I'm good friends with.
Doogie's the most well-known nationally. He was on America's Got Talent last year and became sort of an overnight hit. He's the dude who was about to get booed off the stage but started insulting the crowd which then cheered him on. He also wrote a book called "Everything Explained Through Flowcharts" which is great (I helped him with a few and am even thanked -- one of the true honors of my life). They show up on Boing Boing a lot. He also designed the book cover for Sense and Sensibilities and Sea Monsters. He does a few out-of-town shows and is totally worth seeing.
Chip Chantry's one of the best comics anywhere. He's actually recording an album in a few weeks at Helium in Philly. I think this has a shot to get some notoriety. Chip's great since he looks a little like one of the Karate Kid villains -- typical All-American -- but is completely warped. He also does a lot of more alt-comedy around Philly which is great, since it lets him embrace his internal weirdness even further. He also does a few out-of-town gigs.
Aaron Hertzog's my partner-in-crime on The Holding Court Podcast and frequently mocked by Tom whenever I call in. I really can't say enough good things about him as a person and and a comic. He's the hardest working comic I know in Philly -- he writes more than anyone else and I've never seen him do the same set, and I've seen him a few dozen times. He's starting to get confident enough to try his hand in other cities which he should've started doing three years ago!
The Feeko Brothers are a sketch duo. If there's a more unique sketch group in the country, I'd like to see it. I don't know if they have anything on video but if they really busted their ass, I could totally see them getting to a Tim & Eric type of level. They're seriously THAT good. If you doubt me, I will try my best to personally force you to watch their material. Everyone in the weird Philly comedy scene we have swears by them as the best.
EXCEPT that Secret Pants has a case to make, as well. Secret Pants are kind of the godfathers of Philly comedy. They've been around longer than anyone else. They've also had a bunch of stuff go viral -- they have a video out called "Bush or Batman" in which they read people quotes and quiz people if the statement was said by George W. Bush or 60s era Batman. They also have a video called Juggalo Sunday which was endorsed by ICP themselves!
Also, my brother. I'm frequently mocked by Tom for bringing him up (although, I'll note, Tom's the one who always brings him up whenever I call in). This is out of a sense of familial love, obviously, but he's pretty great and is really great at pushing the boundaries of what can be done in a comedy setting.